Analytical Scientist

工作概览

The Scientist will conduct analytical method development and testing for oligonucleotide pipeline drugs in Brii’s Shanghai laboratory. This individual will be responsible for developing and troubleshooting assays, including those for raw materials, drug substance and drug product to support internal drug candidates and to support oligonucleotide platform technologies. Additionally, the Scientist will work closely with early discovery oligo chemistry team members to characterize novel chemical synthetic processes.  This individual will work both independently and within a team to support internal work as well as that conducted at contract development and manufacturing organizations (CDMOs) and CROs.

工作职责

• Develop internal methodology for analysis of oligonucleotides and raw materials used for oligonucleotide synthesis and delivery, including HPLC (IP-RP, AEX, SEC and UPLC), LC-MS, MS/MS, GC and other analytical technologies. Optimize methods to improve method quality and understanding of product, e.g. impurity identification and profile. Compare results with CDMO(s), troubleshoot issues, and collaborate to improve analyses at the contractor.
• Analyze materials produced by Brii scientists and report results.  Hands on work in laboratory is expected.
• Maintain analytical equipment in good condition and ensure calibration.
• Remain current with latest technology and methods for oligonucleotides and share information across company to ensure Brii’s leadership in area.
• Work closely with laboratory team members to optimize work flow and push forward discovery and early development drug candidates and platforms.
• Provide oversight and support to outside analytical/characterization laboratories as needed to supplement in house activities.
• Provide insight on analytical results and communicate that perspective as well as results to team members.
• Plan experiments and execute with good documentation practice including comprehensive record keeping in the Company Electronic Laboratory Notebook
• Collaborate with broader Tech Ops and Discovery teams, providing analytical oligo expertise to programs.

任职资格

• B.S. in Chemistry, Biology, Chemical Engineering, Bioengineering, Pharmaceutical Science, or related scientific disciplines with 2+ years of experience in the Pharmaceutical or Biotech industry with a focus on oligonucleotide analysis.
• Hands-on academic or industry experience in oligonucleotide analysis, particularly for drug substance but drug product desirable.
• Familiarity with oligonucleotide physiochemical characterization testing.
• Ability to effectively work independently in a team environment with the internal department including but not limited to the Discovery, Technical Operations and Quality Assurance Department in a fast-paced collaborative environment.
• Other skills required:

• Strong laboratory skills and attention to detail and ability to independently develop methodology.
• Good documentation skills including written English, including drafting protocols, reports and data tables.
• Ability to work in a strong internal culture designed around collaboration, feedback, motivation, and accountability.
• Strong communication and interpersonal skills.
• Demonstrated ability to work in fast pace, multi-tasking team environment while meeting deadlines.
• Ability to summarize complex technical information into a concise report, focused on key results.