Principal Investigator, In Vitro Biology

工作概览

Brii Bio is seeking a highly motivated and skilled biologist candidate for our growing drug discovery team. The individual will be working in our state-of-the-art wet laboratory space Shanghai, China. The successful candidate will lead and conduct in vitro experimental biology studies in all phases of exploratory and discovery biology. The position will require a diverse skill set and knowledge base to include cell-free cell-line studies as well as primary cell biology.  A deep understanding of in vitro biology based on oligonucleotide-based therapeutics is important, and it is also necessary to understand in vitro to in vivo translation into preclinical species as well as human studies. The candidate will be required to work independently on a variety of in vitro assays to screen, characterize and evaluate compounds. The individual will also be accountable to identify and develop assays and methods to characterize novel biology, delineate mechanisms to discover new drug candidates. The successful candidate will have a broad understanding of biophysics, biochemistry, cell and molecular biology, human genomics. This role will require working closely with a global discovery team to incorporate new technologies to facilitate the progression of novel clinical candidates that allow for maximal therapeutic impact and differentiation for patients. Primary responsibilities will be laboratory-based activities to design and execute in vitro experimental studies, generate data and report results to a broad program team. The candidate must have good organizational, writing and communication abilities to communicate results and ideas with other team members including non-scientists.

工作职责

• Manage in vitro experimental in vitro research activities.
• Set goals and meet in vitro experimental study timelines and execute in vitro strategy in alignment with the goals and key scientific objectives for the research.
• Conduct lead identification and drug candidate profiling and characterization.
• Perform in vitro or ex vivo cell-based studies to characterize disease biology.
• Maintain knowledge of state-of-the-art principles and theories, and independently apply to the design, execution, and interpretation of experiments to address scientific questions.
• Demonstrate creative ‘out of the box’ thinking to solve problems and modify experimental plans when required to achieve project goals.
• Facilitate the characterization of disease pharmacology, for the development of novel scientific in vitro technologies and cellular models with high translational relevance.
• Prepare, review, and deliver scientific presentations for internal/external use.
• Represent in vitro platform technologies on cross-functional teams.
• Collaborate and manage external CRO teams.
• Ensure all data and results are carefully documented in Brii electronic lab notebook systems. 
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of in vitro experimental materials, controlled drug where applicable.
• Stay current with scientific literature and advancements in the field.
   

任职资格

• PhD, Master or equivalent in biochemistry, cell biology, molecular biology, or a related discipline with 4+ years of experience in industry.
• In-depth knowledge with hands-on experience (preferred) in several key areas including biophysics, biochemistry, molecular biology, cell biology, genetics and pharmacology. 
• Proficiency and expertise in performing a variety of in vitro pharmacological and immunological assays.
• Proficiency and expertise in cell-based screening assays, nucleic acid or oligonucleotide-based assays are required.
• Understanding of advancing platform technology areas including CRISPR/Cas9, gene editing, vector delivery methods, antibody drug conjugates, mRNA vaccine, 3D-cultures/organoids and flow cytometry is a plus.
• Experience designing and executing in vitro drug discovery biology experiments as part of a larger research team is required.
• Demonstrated ability to work independently and collaborate in a team-oriented environment.
• Solid track record of completing challenging technical problems independently and creatively, exemplified by publication of research in high-quality scientific journals.
• Strong written, verbal, and interpersonal communications skills and ability to work efficiently and productively in a dynamic, scientifically rigorous, and fast-paced environment.