Research Associate to Scientist, Oligo Chemistry

SUMMARY

Brii Bio is seeking a skilled oligonucleotide chemist for our growing drug discovery team.  The individual will be working in our state-of-the-art discovery laboratory in Shanghai, China.  The successful candidate for this position will be an expert in synthesis and purification of oligonucleotide constructs including small interfering RNA (siRNA) and antisense oligonucleotide (ASO) modalities.  

DUTIES AND RESPONSIBILITIES

• Synthesis of novel oligonucleotide analogs.
• Design, set-up and preparation of libraries of oligonucleotide analogs.
• Purification of oligonucleotide drug analogs.
• Explore incorporation of novel RNA monomers and other chemistries to design and generate compounds to drive biological understanding including in vitro and in vivo pharmacology models.
• Scale up initial library amounts to supply sufficient drug quantities for advanced in vitro and in vivo studies as needed.
• Optimize synthesis conditions to improve yields and purity.
• Develop analytical methods for purification and characterization of oligonucleotide drug molecules
• Ensure all data and results are carefully documented in Brii electronic lab notebook systems.
• Demonstrate creative ‘out of the box’ thinking to solve problems and modify experimental plans when required to achieve project goals.
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, and controlled drug where applicable.
• Comply with Brii Biosciences environmental health and safety policies and operate in a safe manner.
• Prepare, and deliver scientific presentations for internal/external use.
• Collaborate and manage external CRO teams.
• Work cross-functionally in complex and fast-paced research organization.
• Stay current with scientific literature and advancements in the field.

QUALIFICATIONS

• Master’s degree in chemistry and 1+ year (preferred) or Bachelor’s Degree in chemistry with 3+ years of post-degree experience, preferably in industry working in oligonucleotide synthesis.
• Demonstrated track record of scientific research or publications (preferred).
• Proficiency in chromatographic purification and analytical characterization methods.
• Demonstrated ability to work independently and collaborate in a team-oriented environment.
• Solid track record of completing challenging technical problems.
• Strong written, verbal, and interpersonal communications skills and ability to work efficiently and productively in a dynamic, scientifically rigorous, and fast-paced environment.