Senior to Principle Scientist, DMPK

SUMMARY

Brii Biosciences is seeking a highly motivated and experienced DMPK expert to join our dynamic R&D team. This role will serve as the DMPK subject matter expert across Brii’s portfolio, supporting programs from early discovery through clinical development and regulatory submission. The successfully candidate will have a strong background in drug discovery and development in the pharmaceutical industry including a proven track record for design and execution of in vitro and in vivo studies to support drug candidate progression.   The role involves working at part of a multi-disciplinary global research and development team to profile, characterize and ensure a detailed understanding of the DMPK properties of various program assets.   A good understanding of cross-species translation from rodent to primate and human is a must.  This person will work closely with the safety assessment and in vivo pharmacology teams to ensure the correct studies and interpretation of data are made.   The candidate should have excellent oral and written communication skills and an ability to put results and conclusions into clear context with a wide array of stakeholders.

DUTIES AND RESPONSIBILITIES

• Design, execute, analyze, and interpret in vitro and in vivo ADME, PK and biodistribution studies to support lead optimization and candidate selection
• Contribute to the development and implementation of DMPK strategies to support key preclinical project decisions
• Provide DMPK input into candidate selection, nonclinical species selection, dose and regimen selection, and the design of exploratory pharmacology and toxicology studies
• Participate in the design and execution of DMPK and TK studies for IND-enabling programs & support IND submissions
• Responsible for communication and management of outsourced CROs, as well as overseeing bioanalytical method development, qualification or validation, and sample analysis to ensure data accuracy and reliability, timelines, and compliance
• Collaborate cross-functionally with CMC, preclinical and clinical development teams

QUALIFICATIONS

• A PhD in pharmacology, chemistry, DMPK or a related field with more than 3 years of hands-on DMPK experience or a Master’s in a related field with more than 8 years experience
• Proven experience of independently designing, leading and completing PK, ADME or biodistribution studies
• A good understanding of the DMPK challenges related to long-acting drug development including flip-flop kinetic analysis, experience with cutting-edge formulation technologies, tissue targeting conjugates and biodistribution study methodologies.
• Familiarity with standard DMPK workflows and strong analytical skills including but not limited to LC-MS/MS
• Strong data analysis and problem-solving skills
• Experience supporting candidate selection, exploratory toxicology, or IND-enabling studies is preferred
• Good teamwork and cross-functional communication skills
• Prior experience with RNAi therapeutics is a plus; familiarity with delivery systems including drug conjugates, lipid nanoparticles and their impact on biodistribution and exposure is preferred
• Good English proficiency, with the ability to read scientific literature and communicate effectively in daily work

Preferred Qualifications:

• Familiarity with PK/PD or PBPK modeling and simulation and the application of quantitative approaches to discovery and translational research
• Project management skills, with the ability to drive multiple tasks in parallel